2. Signaling Pathways
  3. MAPK/ERK Pathway
  4. p38 MAPK
  5. p38 MAPK p53 Inhibitor

p38 MAPK p53 Inhibitor

p38 MAPK Isoform Comparison

p38 MAPK p53 Inhibitors (2):

Cat. No. Product Name Effect Purity
  • HY-N18197
    Norkurarinol
    		p53 Inhibitor
    Norkurarinol is a prenylated flavonoid. Norkurarinol can be isolated from Sophora flavescens. Norkurarinol potently inhibits mushroom Tyrosinase DOPA oxidase activity with an IC50 of 2.1 μM. Norkurarinol inhibits poly(I:C)-induced NF-κB/AP-1 activation. Norkurarinol inhibits pro-inflammatory cytokines (TNF-α, IL-6). Norkurarinol inhibits phosphorylation of p38, JNK, and ERK1/2. Norkurarinol increases phosphorylation of IRF3. Norkurarinol has antiviral activity against Rotavirus KJ56-1
  • HY-14412
    p38α inhibitor 4
    		p53 Inhibitor
    p38α inhibitor 4 (compound 10) is a selective and allosteric p38α inhibitor with an IC50 value of 1.2 μM. p38α inhibitor 4 exhibits no activity against p38β, p38γ, and p38δ.